6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine

Base Information

• Chemical Name: 6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine
• CAS No.: 1398564-49-2
• Molecular Formula: C₁₆H₁₀ClN₃O₃S₃
• Molecular Weight: 423.925
• Mol file: 1398564-49-2.mol

Synonyms:6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine

Chemical Property of 6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine

There total 4 articles about 6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-hydroxybenzenecarboximidamide (613-92-3) + 6-chloro-3-(methylthio)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxylic acid → 6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine (1398564-49-2)

Guidance literature:

6-chloro-3-(methylthio)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxylic acid; With thionyl chloride; In benzene; for 1h; Reflux;

N-hydroxybenzenecarboximidamide; In toluene; benzene; at 0 - 110 ℃;

DOI:10.1016/j.ejmech.2012.07.042

Reference yield:

6-chloro-3-(methylthio)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxylic acid → 6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine (1398564-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / benzene / Reflux

2: toluene / 0 - 20 °C

3: 110 °C

With thionyl chloride; In toluene; benzene;

DOI:10.3390/molecules201219821

Reference yield:

chlorek kwasu 6-chloro-3-metylotio-1,1-diokso-1,4,2-benzoditiazyno-7-karboksylowego (156775-41-6) → 6-chloro-3-methylthio-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine (1398564-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 0 - 20 °C

2: 110 °C

In toluene;

DOI:10.3390/molecules201219821

upstream raw materials:

N-hydroxybenzenecarboximidamide

chlorek kwasu 6-chloro-3-metylotio-1,1-diokso-1,4,2-benzoditiazyno-7-karboksylowego

Downstream raw materials:

C₂₂H₁₈ClN₅O₄S₂

3-amino-6-chloro-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,1-dioxo-1,4,2-benzodithiazine

C₂₅H₂₄ClN₅O₇S₂

C₂₃H₁₈ClN₅O₆S₂