(4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone

Base Information

Chemical Name:(4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone
CAS No.:263716-53-6
Molecular Formula:C₂₆H₂₅NO₄
Molecular Weight:415.489
Hs Code.:

Synonyms:(4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone

Chemical Property:

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Technology Process of (4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone

There total 1 articles about (4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 40478-49-7
3-(3-methoxyphenyl)propanoyl chloride

: 173604-33-6,312624-01-4
(4R)-4-(diphenylmethyl)-2-oxazolidinone

: 263716-53-6
(4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone

Guidance literature:: (4R)-4-(diphenylmethyl)-2-oxazolidinone; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

3-(3-methoxyphenyl)propanoyl chloride; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;
DOI:10.1139/v99-220

Reference yield: 85.0%

: 49827-15-8
t-butyl iodoacetate

: 263716-53-6
(4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone

: 263716-54-7
(4R)-4-(diphenylmethyl)-3-[[(2S)-2-(tert-butyloxycarbonyl)methyl-3-(3'-methoxyphenyl)]propanoyl]-2-oxazolidinone

Guidance literature:: (4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

t-butyl iodoacetate; In tetrahydrofuran; at -78 ℃; for 6h;
DOI:10.1139/v99-220

Reference yield:

: 263716-53-6
(4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone

: (3S,4S)-3,4-bis[(3-hydroxyphenyl)methyl]dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 85 percent / tetrahydrofuran / 6 h / -78 °C

2.1: 85 percent / aq. H₂O₂; aq. LiOH / tetrahydrofuran / 4.5 h / 0 - 20 °C

3.1: BH₃*THF / tetrahydrofuran / 2.5 h / 0 - 20 °C

3.2: 92 percent / PTSA / benzene / 2 h / Heating

4.1: NaHMDS / tetrahydrofuran / 1.25 h / -78 °C

4.2: 69 percent / tetrahydrofuran / 22 h / -54 °C

5.1: 78 percent / BBr₃ / CH₂Cl₂ / -18 - 0 °C

With lithium hydroxide; borane-THF; dihydrogen peroxide; sodium hexamethyldisilazane; boron tribromide; In tetrahydrofuran; dichloromethane; 1.1: Metallation / 1.2: Alkylation / 2.1: Hydrolysis / 3.1: Reduction / 3.2: Cyclization / 4.1: Metallation / 4.2: Alkylation / 5.1: demethylation;
DOI:10.1139/v99-220