tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid

Base Information

Chemical Name:tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid
CAS No.:263716-55-8
Molecular Formula:C₁₆H₂₂O₅
Molecular Weight:294.348
Hs Code.:

Synonyms:tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid

Suppliers and Price of tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid

There total 3 articles about tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 263716-54-7
(4R)-4-(diphenylmethyl)-3-[[(2S)-2-(tert-butyloxycarbonyl)methyl-3-(3'-methoxyphenyl)]propanoyl]-2-oxazolidinone

: 263716-55-8
tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h;
DOI:10.1139/v99-220

Reference yield:

: 40478-49-7
3-(3-methoxyphenyl)propanoyl chloride

: 263716-55-8
tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 93 percent / tetrahydrofuran; hexane / 2.5 h / -78 °C

2.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 85 percent / tetrahydrofuran / 6 h / -78 °C

3.1: 85 percent / aq. H₂O₂; aq. LiOH / tetrahydrofuran / 4.5 h / 0 - 20 °C

With lithium hydroxide; n-butyllithium; dihydrogen peroxide; sodium hexamethyldisilazane; In tetrahydrofuran; hexane; 1.1: Metallation / 1.2: Acylation / 2.1: Metallation / 2.2: Alkylation / 3.1: Hydrolysis;
DOI:10.1139/v99-220

Reference yield:

: 263716-53-6
(4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone

: 263716-55-8
tert-butyloxycarbonyl (2S)-2-(carboxymethyl)-3-(3'-methoxyphenyl)propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 85 percent / tetrahydrofuran / 6 h / -78 °C

2.1: 85 percent / aq. H₂O₂; aq. LiOH / tetrahydrofuran / 4.5 h / 0 - 20 °C

With lithium hydroxide; dihydrogen peroxide; sodium hexamethyldisilazane; In tetrahydrofuran; 1.1: Metallation / 1.2: Alkylation / 2.1: Hydrolysis;
DOI:10.1139/v99-220