(R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate

Base Information

• Chemical Name: (R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate
• CAS No.: 1229380-22-6
• Molecular Formula: C₂₄H₂₅ClN₂O₃S
• Molecular Weight: 456.993
• Mol file: 1229380-22-6.mol

Synonyms:(R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate

Chemical Property of (R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate

There total 1 articles about (R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-(o-chlorophenyl)-1,3-thiazol-2-amine (21344-90-1) + (2R)-3-tert-Butyloxycarbonyl-2-phenylmethylpropionic Acid (122225-33-6) → (R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate (1229380-22-6)

Guidance literature:

(2R)-3-tert-Butyloxycarbonyl-2-phenylmethylpropionic Acid; With HATU; In N,N-dimethyl-formamide; for 0.0833333h;

4-(o-chlorophenyl)-1,3-thiazol-2-amine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 96h;

Reference yield: 99.0%

(R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate (1229380-22-6) → (R)-3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoic acid (1229359-02-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

upstream raw materials:

4-(o-chlorophenyl)-1,3-thiazol-2-amine

(2R)-3-tert-Butyloxycarbonyl-2-phenylmethylpropionic Acid

Downstream raw materials:

(R)-3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoic acid