Przewalskinic acid A

Base Information

• Chemical Name: Przewalskinic acid A
• CAS No.: 136112-75-9
• Molecular Formula: C18H14O8
• Molecular Weight: 358.3
• Mol file: 136112-75-9.mol

Synonyms:

Chemical Property of Przewalskinic acid A

Chemical Property:

• PSA: 144.52000
• LogP: 2.37070

Purity/Quality:

≥98% ^*data from raw suppliers

PrzewalskinicacidA 98.64% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Przewalskinic acid A

There total 24 articles about Przewalskinic acid A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C36H54O8Si2 (1609692-00-3) → (-)-trans-blechnic acid (136112-75-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0033-1340291

Reference yield:

lithospermic acid → danshensu (23028-17-3,42085-50-7,69339-96-4,76822-21-4) + (-)-7-epi-blechnic acid (136112-75-9)

Guidance literature:

With sodium hydroxide; In water; for 2h;

DOI:10.1016/j.fitote.2013.08.009

Reference yield:

salvianolic acid B (115939-25-8) → danshensu (23028-17-3,42085-50-7,69339-96-4,76822-21-4) + (-)-7-epi-blechnic acid (136112-75-9)

Guidance literature:

With sodium hydroxide; In water; for 2h;

DOI:10.1016/j.fitote.2013.08.009

upstream raw materials:

salvianolic acid B

(2S,3R)-2-{3,4-bis(triisopropylsilyloxy)phenyl}-7-(methoxymethoxy)-2,3-dihydrobenzofuran-3-carboxylic acid

(2S,3R)-2-{3,4-bis(triisopropylsilyloxy)phenyl}-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylic acid

(2S,3R)-2-{3,4-bis(triisopropylsilyloxy)phenyl}-7-hydroxy-4-{(E)-3-oxo-3-(2,2,2-trichloroethoxy)prop-1-en-1-yl}-2,3-dihydrobenzofuran-3-carboxylic acid

Refernces

• 1、 Wang,Davin,Lewis. "Stereoselective phenolic coupling in Blechnum spicant: Formation of 8-2′ linked (-)-cis-blechnic, (-)-trans-blechnic and (-)-brainic acids". . p. 113 - 114. Retrieved 2001.
• 2、 Ito, Motoki,Namie, Ryosuke,Krishnamurthi, Janagiraman,Miyamae, Hitomi,Takeda, Koji,Nambu, Hisanori,Hashimoto, Shunichi. "Asymmetric Total Synthesis of (-)- trans -Blechnic Acid via Rhodium(II)-Catalyzed C-H Insertion and Palladium(II)-Catalyzed C-H Olefination Reactions". . p. 288 - 292. Retrieved 2014/02/14.
• 3、 -. "Derivatives of 8-epiblechnic Acid and their Effects on Down-Regulation of Endothelin (ETA) receptor mRNA". Page/Page column 3-4. . Retrieved 2010/03/31.