5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester

Base Information

• Chemical Name: 5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester
• CAS No.: 1026273-16-4
• Molecular Formula: C₃₁H₃₂N₂O₅
• Molecular Weight: 512.605
• Mol file: 1026273-16-4.mol

Synonyms:5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester

Chemical Property of 5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester

There total 2 articles about 5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{[4-(chloromethyl)phenoxy]methyl}-5-methyl-2-phenyl-1,3-oxazole (250602-53-0) + ethyl (E)-5-(hydroxyimino)-5-phenylpentanoate (250602-58-5) → 5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester (1026273-16-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

DOI:10.1248/cpb.51.138

Reference yield:

ethyl 4-benzoylbutanoate (73172-56-2) → 5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester (1026273-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / hydroxylamine hydrochloride; sodium acetate / ethanol / 15 h / Heating

2: sodium hydride / dimethylformamide / 2 h / 0 °C

With hydroxylamine hydrochloride; sodium acetate; sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.51.138

Reference yield: 80.0%

5-[(E)-4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-benzyloxyimino]-5-phenyl-pentanoic acid ethyl ester (1026273-16-4) → (E)-5-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-5-phenylpentanoic acid

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

DOI:10.1248/cpb.51.138

upstream raw materials:

4-{[4-(chloromethyl)phenoxy]methyl}-5-methyl-2-phenyl-1,3-oxazole

ethyl (E)-5-(hydroxyimino)-5-phenylpentanoate

ethyl 4-benzoylbutanoate