5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Base Information

• Chemical Name: 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide
• CAS No.: 920003-09-4
• Molecular Formula: C₂₁H₁₇ClN₄O₃
• Molecular Weight: 408.844
• Mol file: 920003-09-4.mol

Synonyms:5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Chemical Property of 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Chemical Property:

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MSDS Files:

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Technology Process of 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

There total 1 articles about 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (920002-74-0) + 1,3-dimethyl-5-chloro-pyrazole-4-carbonyl chloride (27006-83-3) → 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (920003-09-4)

Guidance literature:

In tetrahydrofuran; for 2h; Heating / reflux;

Reference yield: 59.0%

5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (920003-09-4) + formic acid ethyl ester (109-94-4) → 5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (920003-10-7)

Guidance literature:

5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide; formic acid ethyl ester; With sodium ethanolate; In ethanol; at 78 ℃; for 1h;

With hydrogenchloride; water; In ethanol; at 20 ℃; pH=1;

upstream raw materials:

6-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one

1,3-dimethyl-5-chloro-pyrazole-4-carbonyl chloride

Downstream raw materials:

5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide