2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine

Base Information

Chemical Name:2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine
CAS No.:1198473-41-4
Molecular Formula:C₃₂H₃₂N₄O₃SSi
Molecular Weight:580.783
Hs Code.:

Synonyms:2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine

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Chemical Property of 2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine

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Technology Process of 2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine

There total 6 articles about 2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198473-40-3
2-Bromo-4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridine

: 1198473-39-0
2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)imidazo[1,2-a]pyridine hydrobromide

: 1198473-41-4
2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

: 394653-94-2
6-(Ν-methoxy-N-methyl)-1H-indole-6-carboxamide

: 1198473-41-4
2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.1: tetrahydrofuran; diethyl ether / 21 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C

3.1: copper bromide / ethyl acetate / 4 h / Reflux

4.1: ethanol / 20 h / Reflux

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere

With sodium hydride; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1198473-36-7
N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide

: 1198473-41-4
2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 21 h / 0 - 20 °C / Inert atmosphere

1.2: 0 °C

2.1: copper bromide / ethyl acetate / 4 h / Reflux

3.1: ethanol / 20 h / Reflux

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere

With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; ethanol; water; ethyl acetate;