N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide

Base Information

• Chemical Name: N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide
• CAS No.: 1198473-36-7
• Molecular Formula: C₁₇H₁₆N₂O₄S
• Molecular Weight: 344.391
• Mol file: 1198473-36-7.mol

Synonyms:N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide

Chemical Property of N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide

There total 2 articles about N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(Ν-methoxy-N-methyl)-1H-indole-6-carboxamide (394653-94-2) + benzenesulfonyl chloride (98-09-9) → N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide (1198473-36-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

Indole-6-carboxylic acid (1670-82-2,261352-47-0) → N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide (1198473-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 40 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

With pyridine; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide (1198473-36-7) + methylmagnesium bromide (75-16-1) → 6-acetyl-1-(phenylsulphonyl)indole (1198473-37-8)

Guidance literature:

N-Methoxy-N-methyl-1-(phenylsulphonyl)indole-6-carboxamide; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 21h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃;

upstream raw materials:

6-(Ν-methoxy-N-methyl)-1H-indole-6-carboxamide

benzenesulfonyl chloride

Indole-6-carboxylic acid

Downstream raw materials:

6-acetyl-1-(phenylsulphonyl)indole

2-bromo-1-[1-(phenylsulphonyl)indol-6-yl]ethanone

2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)imidazo[1,2-a]pyridine hydrobromide

2-(1-Phenylsulphonyl-1H-indol-6-yl)-6-[4-[1-methyl-1-(trimethylsilanyloxy)ethyl]pyridin-2-yl]imidazo[1,2-a]pyridine