Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester

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Chemical Name:Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester
CAS No.:181772-05-4
Molecular Formula:C₃₀H₃₇F₃O₇S
Molecular Weight:598.681
Hs Code.:

Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester

Synonyms:Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester

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Technology Process of Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester

There total 3 articles about Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 181772-02-1
(1S,7aR)-1-(4-Methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-1,2,3,6,7,7a-hexahydro-inden-5-one

: 181772-05-4
Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; -78 deg C -> room temperature;
DOI:10.1021/jo961209r

Reference yield:

: 181771-97-1
(1S,7aR)-1-(4-Methoxy-benzyloxymethyl)-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

: 181772-05-4
Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent

2: 1) LiNEt₂, 2) NaOAc, AcOH / 1) THF, HMPA, -78 deg C -> room temperature, 2) THF, H₂O

3: 83 percent / KHMDS / tetrahydrofuran / -78 deg C -> room temperature

With lithium diethylamide; sodium acetate; potassium hexamethylsilazane; acetic acid; In tetrahydrofuran;
DOI:10.1021/jo961209r

Reference yield:

: N'-[(1S,7aR)-1-(4-Methoxy-benzyloxymethyl)-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-(5Z)-ylidene]-N,N-dimethyl-hydrazine

: 181772-05-4
Trifluoro-methanesulfonic acid (1S,7aR)-1-(4-methoxy-benzyloxymethyl)-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,7,7a-tetrahydro-1H-inden-5-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LiNEt₂, 2) NaOAc, AcOH / 1) THF, HMPA, -78 deg C -> room temperature, 2) THF, H₂O

2: 83 percent / KHMDS / tetrahydrofuran / -78 deg C -> room temperature

With lithium diethylamide; sodium acetate; potassium hexamethylsilazane; acetic acid; In tetrahydrofuran;
DOI:10.1021/jo961209r