2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol

Base Information

Chemical Name:2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol
CAS No.:1380094-11-0
Molecular Formula:C₂₄H₂₇F₂N₅O₃
Molecular Weight:471.507
Hs Code.:

Synonyms:2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol

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Chemical Property of 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol

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Technology Process of 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol

There total 16 articles about 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1380094-33-6
methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate

: 1380094-11-0
2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol

Guidance literature:: methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate; With lithium borohydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1.5h;

With sodium hydroxide; pH=8; Product distribution / selectivity;

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 1380094-11-0
2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / 0 - 20 °C / Cooling with ice

2.1: ammonium acetate / 1,4-dioxane / 1 h / 20 - 25 °C / Inert atmosphere

2.2: 14 h / 20 - 25 °C

2.3: 7 h / 10 - 25 °C

3.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 2 h / 0 - 30 °C / Inert atmosphere

3.2: 3 h / 0 - 25 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 15 - 25 °C

5.1: ethanol / 20 °C

5.2: 20 h / Reflux

6.1: lithium borohydride / diethyl ether; tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

6.2: 1.5 h / 20 °C

6.3: pH 8

With lithium borohydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; sulfuric acid; ammonium acetate; hydrogen; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1380094-29-0
1-(6-amino-S-nitro-2-pyridyl)-2-(2,4-difluorophenyl)ethane-1,2-dione

: 1380094-11-0
2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / 1,4-dioxane / 1 h / 20 - 25 °C / Inert atmosphere

1.2: 14 h / 20 - 25 °C

1.3: 7 h / 10 - 25 °C

2.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 2 h / 0 - 30 °C / Inert atmosphere

2.2: 3 h / 0 - 25 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 15 - 25 °C

4.1: ethanol / 20 °C

4.2: 20 h / Reflux

5.1: lithium borohydride / diethyl ether; tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 1.5 h / 20 °C

5.3: pH 8

With lithium borohydride; sulfuric acid; ammonium acetate; hydrogen; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water; dimethyl sulfoxide;