methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate

Base Information

Chemical Name:methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate
CAS No.:1380094-33-6
Molecular Formula:C₂₅H₂₇F₂N₅O₄
Molecular Weight:499.517
Hs Code.:

Synonyms:methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate

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Chemical Property of methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate

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Technology Process of methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate

There total 14 articles about methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1380094-27-8
(3S)-3-isothiocyanato-1-methoxy-butane

: 1380094-32-5
methyl 2-[4-(5-amino-6-hydroxy-2-pyridyl)-5-(2,4-difluorophenyl)-1H-imidazol-2-yl]-2-methyl-propanoate

: 1380094-33-6
methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate

Guidance literature:: (3S)-3-isothiocyanato-1-methoxy-butane; methyl 2-[4-(5-amino-6-hydroxy-2-pyridyl)-5-(2,4-difluorophenyl)-1H-imidazol-2-yl]-2-methyl-propanoate; In ethanol; at 20 ℃;

With dicyclohexyl-carbodiimide; In ethanol; for 20h; Product distribution / selectivity; Reflux;

Reference yield:

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 1380094-33-6
methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.17 h / 0 - 5 °C / Inert atmosphere

1.2: 1 h / 30 °C

2.1: disodium hydrogenphosphate; potassium permanganate; sodium dihydrogenphosphate / water; acetone / 5 h / 0 - 15 °C / Inert atmosphere

2.2: 1 h / 15 - 20 °C

3.1: ammonium acetate / 1,4-dioxane / 1 h / 20 - 25 °C / Inert atmosphere

3.2: 14 h / 20 - 25 °C

3.3: 7 h / 10 - 25 °C

4.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 2 h / 0 - 30 °C / Inert atmosphere

4.2: 3 h / 0 - 25 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 15 - 25 °C

6.1: ethanol / 20 °C

6.2: 20 h / Reflux

With potassium permanganate; disodium hydrogenphosphate; sodium dihydrogenphosphate; sulfuric acid; ammonium acetate; hydrogen; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; acetone; acetonitrile;

Reference yield:

: 13865-20-8
methyl 2,2-dimethyl-3-oxopropanoate

: 1380094-33-6
methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / 1,4-dioxane / 1 h / 20 - 25 °C / Inert atmosphere

1.2: 14 h / 20 - 25 °C

1.3: 7 h / 10 - 25 °C

2.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 2 h / 0 - 30 °C / Inert atmosphere

2.2: 3 h / 0 - 25 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 15 - 25 °C

4.1: ethanol / 20 °C

4.2: 20 h / Reflux

With sulfuric acid; ammonium acetate; hydrogen; sodium nitrite; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide;