N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester

Base Information

• Chemical Name: N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester
• CAS No.: 151012-00-9
• Molecular Formula: C₃₄H₃₄N₂O₃S
• Molecular Weight: 550.722
• Mol file: 151012-00-9.mol

Synonyms:N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester

Chemical Property of N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester

There total 3 articles about N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Sulfanylpyridine (2637-34-5,73018-10-7) + Nα-trityl-L-aspartic acid β-cyclohexyl ester (151036-42-9) → N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester (151012-00-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; at 0 - 20 ℃;

DOI:10.1021/jm9508043

Reference yield:

Boc-Asp(O-cyclohexyl)-OH (73821-95-1) → N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester (151012-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂ / 0.75 h / Ambient temperature

2: 1.) Me₃SiCl, Et₃N, 2.) MeOH

3: 83 percent / DCC / ethyl acetate / 0 - 20 °C

With methanol; chloro-trimethyl-silane; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; ethyl acetate;

DOI:10.1021/jm9508043

Reference yield:

β-cyclohexyl L-aspartate (112259-66-2) → N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester (151012-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Me₃SiCl, Et₃N, 2.) MeOH

2: 83 percent / DCC / ethyl acetate / 0 - 20 °C

With methanol; chloro-trimethyl-silane; triethylamine; dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1021/jm9508043

upstream raw materials:

2-Sulfanylpyridine

N^α-trityl-L-aspartic acid β-cyclohexyl ester

Boc-Asp(O-cyclohexyl)-OH

β-cyclohexyl L-aspartate

Downstream raw materials:

cyclohexyl 3(S)-3-(tritylamino)-4-oxo-6-isopropyloct-7-enoate

cyclohexyl 3(S)-3-(tritylamino)-4-oxo-6-isopropyloct-7-enoate

cyclohexyl 3-[(tert-butyloxycarbonyl)amino]-4-oxo-6-methyl-7-octenoate

cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate