(E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate

Base Information

Chemical Name:(E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate
CAS No.:1616119-27-7
Molecular Formula:C₁₉H₂₀ClNO₅
Molecular Weight:377.825
Hs Code.:

Synonyms:(E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate

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Chemical Property of (E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate

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Technology Process of (E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate

There total 4 articles about (E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 15952-61-1
6-chloropiperonal

: 1616119-21-1
(2-((2-(ethoxycarbonyl)cyclohex-1-en-1-yl)amino)-2-oxoethyl)triphenylphosphonium bromide

: 1616119-27-7
(E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2014.05.011

Reference yield:

: 1616119-20-0
ethyl 2-(2-bromoacetamido)cyclohex-1-enecarboxylate

: 1616119-27-7
(E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 3 h / Reflux

2: potassium carbonate; 18-crown-6 ether / dichloromethane / 24 h / 20 °C

With 18-crown-6 ether; potassium carbonate; In dichloromethane; benzene; 2: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.05.011

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1616119-27-7
(E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol / 24 h / 20 °C

2: pyridine / tetrahydrofuran / 1.75 h / -5 °C

3: benzene / 3 h / Reflux

4: potassium carbonate; 18-crown-6 ether / dichloromethane / 24 h / 20 °C

With pyridine; 18-crown-6 ether; ammonia; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; benzene; 4: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.05.011