2-phenyl-2-(propylamino)cyclohexanone

Base Information

• Chemical Name: 2-phenyl-2-(propylamino)cyclohexanone
• CAS No.: 7015-53-4
• Molecular Formula: C₁₅H₂₁NO
• Molecular Weight: 231.338

Synonyms:2-phenyl-2-(propylamino)cyclohexanone

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Chemical Property of 2-phenyl-2-(propylamino)cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-2-(propylamino)cyclohexanone

There total 5 articles about 2-phenyl-2-(propylamino)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

propylamine (107-10-8,42939-71-9) + 2-hydroxy-2-phenylcyclohexanone (4829-02-1) → phenyl(1-(propylamino)cyclopentyl)methanone (7141-84-6) + 2-phenyl-2-(propylamino)cyclohexanone (7015-53-4)

Guidance literature:

at 200 ℃; Inert atmosphere;

DOI:10.3390/molecules17066808

Reference yield:

1,4-dioxaspiro[4.5]decan-6-one (4746-96-7) → phenyl(1-(propylamino)cyclopentyl)methanone (7141-84-6) + 2-phenyl-2-(propylamino)cyclohexanone (7015-53-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 14 h / -78 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / water / 3 h / 0 - 20 °C

3: 200 °C / Inert atmosphere

With trifluoroacetic acid; In tetrahydrofuran; diethyl ether; water;

DOI:10.3390/molecules17066808

Reference yield:

6-phenyl-1,4-dioxaspiro[4.5]decan-6-ol (1422566-95-7) → phenyl(1-(propylamino)cyclopentyl)methanone (7141-84-6) + 2-phenyl-2-(propylamino)cyclohexanone (7015-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / water / 3 h / 0 - 20 °C

2: 200 °C / Inert atmosphere

With trifluoroacetic acid; In water;

DOI:10.3390/molecules17066808

upstream raw materials:

propylamine

2-hydroxy-2-phenylcyclohexanone

1,4-dioxaspiro[4.5]decan-6-one

6-phenyl-1,4-dioxaspiro[4.5]decan-6-ol