(E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile

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Chemical Name:(E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile
CAS No.:1268717-93-6
Molecular Formula:C₁₆H₂₅NO₂
Molecular Weight:263.38
Hs Code.:

Synonyms:(E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile

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Chemical Property of (E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile

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Technology Process of (E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile

There total 1 articles about (E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 766-05-2
cyclohexane carbonitrile

: 98234-53-8,119343-29-2
(E)-2-((4-bromobut-2-en-1-yl)oxy)tetrahydro-2H-pyran

: 1268717-93-6
(E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile

Guidance literature:: cyclohexane carbonitrile; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(E)-2-((4-bromobut-2-en-1-yl)oxy)tetrahydro-2H-pyran; In tetrahydrofuran; hexane; at -78 - 23 ℃;
DOI:10.1021/ol103175w

Reference yield:

: 1268717-93-6
(E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile

: C₁₆H₂₉NO₂

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 23 ℃;
DOI:10.1021/ol103175w

Reference yield:

: 1268717-93-6
(E)-1-(4-(tetrahydro-2H-pyran-2-yloxy)but-2-en-1-yl)cyclohexanecarbonitrile

: 1268717-82-3
1-(N-benzylamino)-4-spirocyclohexyl-2-vinylpyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / diethyl ether / 0 - 23 °C

2: methanol / 6 h / 23 °C / Molecular sieve

3: sodium tetrahydroborate / methanol / 0 - 23 °C

4: hydrogenchloride / methanol; water / 2 h / 23 °C

5: silver hexafluoroantimonate; [AuCl[P(tBu)2(o-biphenyl)]] / 1,4-dioxane / 2 h / 23 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; silver hexafluoroantimonate; lithium aluminium tetrahydride; [AuCl[P(tBu)2(o-biphenyl)]]; In 1,4-dioxane; methanol; diethyl ether; water;
DOI:10.1021/ol103175w