4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime

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Chemical Name:4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime
CAS No.:1202388-91-7
Molecular Formula:C₂₂H₂₆ClN₇O
Molecular Weight:439.948
Hs Code.:

Synonyms:4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime

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Chemical Property of 4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime

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Technology Process of 4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime

There total 6 articles about 4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202389-45-4
4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)cyclohexanone

: 1202388-91-7
4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In methanol; at 70 ℃; for 2h;

Reference yield:

: 15540-81-5
1-bromo-2,5-dimethyl-4-nitrobenzene

: 1202388-91-7
4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; 1,2-dimethoxyethane / 0.25 h / 130 °C / microwave

2.1: hydrogen / palladium 10% on activated carbon / methanol / 760.05 Torr

3.1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 14 h / 125 °C / Sealed

3.2: 5 h / 20 °C

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / 70 °C

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; isopropyl alcohol;

Reference yield:

: 680596-79-6
4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane

: 1202388-91-7
4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)-cyclohexanone oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; 1,2-dimethoxyethane / 0.25 h / 130 °C / microwave

2.1: hydrogen / palladium 10% on activated carbon / methanol / 760.05 Torr

3.1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 14 h / 125 °C / Sealed

3.2: 5 h / 20 °C

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / 70 °C

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; isopropyl alcohol;