680596-79-6

Basic information

• Product Name: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
• Synonyms: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER;4,4,5,5-Tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane;1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1,4-dioxaspiro[4.5]dec-7-en-8-ylboronate;2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene;2-(1,4-Dioxaspiro[4.5]dec-8-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester 0901
• CAS NO: 680596-79-6
• Molecular Formula: C₁₄H₂₃BO₄
• Molecular Weight: 266.14
• EINECS: 1312995-182-4
• Product Categories: blocks;BoronicAcids;Organic boronic acid
• Mol File: 680596-79-6.mol
• Article Data: 25

Chemical Properties

• Melting Point: 60-62°C
• Boiling Point: 313.9°C at 760 mmHg
• Flash Point: 143.7°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 0.000888mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER(680596-79-6)
• EPA Substance Registry System: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER(680596-79-6)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 680596-79-6(Hazardous Substances Data)

Usage

General Description

1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER is a chemical compound that features a boronic acid functional group and a pinacol ester moiety. It is a spirocyclic compound with a boron atom at the 8th position and a six-membered cyclic ether ring. 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER is characterized by its unique structure and has potential applications in organic synthesis, medicinal chemistry, and material science. It may be used as a reagent in organic transformations and as a building block for the synthesis of complex organic molecules. Additionally, its boronic acid functionality may enable it to participate in Suzuki-Miyaura cross-coupling reactions and other important synthetic transformations.

InChI:InChI=1/C14H23BO4/c1-12(2)13(3,4)19-15(18-12)11-5-7-14(8-6-11)16-9-10-17-14/h5H,6-10H2,1-4H3

Upstream product

• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 170011-47-9 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate 
• 73183-34-3 bis(pinacol)diborane 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 1019928-47-2 4-((S)-4-tert-butoxycarbonyl-2-{[6-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-2-phenyl-pyridine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 178363-74-1 C₁₀H₁₂OS 
• 850567-90-7 1,4-dioxaspiro[4.5]dec-7-en-8-ylboronic acid 
• 1352931-41-9 N-(1-(4-(3-hydroxypyridin-2-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide 
• 1252689-21-6 4-(3-hydroxy-pyridin-2-yl)-cyclohexanone 
• 1252615-88-5 [4-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-phenyl]-acetonitrile 
• 1202389-31-8 2-fluoro-5-methyl-4-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)aniline 
• 1202389-28-3 8-(2,5-dimethyl-4-nitrophenyl)-1,4-dixoaspiro[4.5]dec-7-ene 
• 1089280-36-3 8-[3-(methyloxy)-4-nitrophenyl]-1,4-dioxaspiro[4.5]dec-7-ene 
• 959939-45-8 benzyl ((4-(1,4-dioxaspiro)[4.5] dec-7-en-8-yl)phenyl)carbamate 
• 1393685-67-0 4-(4-amino-2,5-difluorophenyl)cyclohexanone 
• 1393686-10-6 4-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-2,5-difluoro-phenylamine 
• 1407965-47-2 4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime 
• 1393685-66-9 4-(1,4-dioxa-spiro[4.5]dec-8-yl)-2,5-difluorophenylamine 

Relevant articles and documents

BICYCLOHEPTANE PYRROLIDINE OREXIN RECEPTOR AGONISTS

The present invention is directed to bicyclo[4.1.0]heptane pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Development of a Stereoselective and Scalable Synthesis for the Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor, BMT-297376; N-((R)-1-((cis)-4-(3-(Difluoromethyl)-2-methoxypyridin-4-yl)cyclohexyl)propyl)-6-methoxynicotinamide

The current work describes a stereoselective and scalable route to N-((R)-1-((cis)-4-(3-(difluoromethyl)-2-methoxypyridin-4-yl)cyclohexyl)propyl)-6-methoxynicotinamide (1) from readily available 1,4-dioxaspiro[4.5]decan-8-one. The developed process encompasses an efficient 1,4-trans-selective synthesis of (trans)-4-(3-(difluoromethyl)-2-methoxypyridin-4-yl)cyclohexyl methanesulfonate as the key intermediate and the use of Ellman sulfinamine methodology to install an alkyl amine in a stereoselective manner. Various synthetic routes were screened to accomplish a stereoselective and scalable protocol to access the title compound (1). This advancement enabled a competent route to the title compound in an enantioselective, safe, cost-effective, and scalable manner.

SPIRO COMPOUND AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR

Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. The inhibitor of the present invention has a structure as represented by general formula (I), wherein the definitions of Ar, E, Y, X, V, D, W, B, ring A and ring B are as shown in the description and claims. Also disclosed in the present invention is a preparation method for the inhibitor. The compound of general formula (I) of the present invention can be used as an indoleamine-2,3-dioxygenase inhibitor for preparing a medicament for preventing and/or treating indoleamine-2,3-dioxygenase-mediated diseases.