6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile

Base Information

• Chemical Name: 6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile
• CAS No.: 128666-81-9
• Molecular Formula: C₁₃H₁₁N₃OS
• Molecular Weight: 257.316

Synonyms:6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile

Chemical Property of 6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile

Chemical Property:

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Technology Process of 6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile

There total 9 articles about 6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methylisothiourea sulphate (14527-26-5,867-44-7,147895-43-0) + 4-methyl-benzaldehyde (104-87-0) + ethyl 2-cyanoacetate (105-56-6) → 6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile (128666-81-9)

Guidance literature:

With sodium hydroxide; In methanol; at 70 ℃; for 0.5h;

DOI:10.1007/s11164-011-0434-4

Reference yield: 88.0%

4‐oxo‐2‐thioxo‐6‐(p-tolyl)‐1,2,3,4‐tetrahydropyrimidine‐5‐carbonitrile (70638-53-8) + methyl iodide (74-88-4) → 5-cyano-6-(4-methylphenyl)-2-(methylthio)uracil (128666-81-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 60 ℃; for 1h;

DOI:10.1002/jhet.686

Reference yield: 86.0%

Potassium; 5-cyano-4-oxo-6-p-tolyl-1,4-dihydro-pyrimidine-2-thiolate + methyl iodide (74-88-4) → 6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile (128666-81-9)

Guidance literature:

In ethanol; Ambient temperature;

DOI:10.1080/07328319708001360

upstream raw materials:

4‐oxo‐2‐thioxo‐6‐(p-tolyl)‐1,2,3,4‐tetrahydropyrimidine‐5‐carbonitrile

methyl iodide

4-methyl-benzaldehyde

2-methylisothiourea sulphate

Downstream raw materials:

4-chloro-6-(4-methylphenyl)-2-methylthiopyrimidine-5-carbonitrile

1-Methyl-2-methylsulfanyl-6-oxo-4-p-tolyl-1,6-dihydro-pyrimidine-5-carbonitrile

5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one

6-cyano-8-methyl-5-(4-methylphenyl)-1,2,4-triazolo<3,4-b>pyrimidin-4-one

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