tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

Base Information

Chemical Name:tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate
CAS No.:1615249-91-6
Molecular Formula:C₂₃H₃₁Cl₂N₃O₄
Molecular Weight:484.423
Hs Code.:

Synonyms:tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

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Chemical Property of tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

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Technology Process of tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

There total 4 articles about tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 879275-33-9
(R)-1-piperidin-3-ylmethyl-carbamic acid tert-butyl ester

: 59749-37-0
C₁₂H₁₁Cl₂NO₃

: 1615249-91-6
tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

Guidance literature:: C₁₂H₁₁Cl₂NO₃; With triethylamine; In dichloromethane; at -20 ℃; for 0.166667h; Inert atmosphere;

With isobutyl chloroformate; In dichloromethane; at -20 ℃; for 0.25h; Inert atmosphere;

(R)-1-piperidin-3-ylmethyl-carbamic acid tert-butyl ester; In dichloromethane; at -20 - 20 ℃; for 1.16667h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 20443-98-5
2,6-Dichlorobenzyl bromide

: 1615249-91-6
tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 0.17 h / -20 °C / Inert atmosphere

3.2: 0.25 h / -20 °C / Inert atmosphere

3.3: 1.17 h / -20 - 20 °C / Inert atmosphere

With water; sodium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 59749-20-1
C₁₃H₁₃Cl₂NO₃

: 1615249-91-6
tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / -20 °C / Inert atmosphere

2.2: 0.25 h / -20 °C / Inert atmosphere

2.3: 1.17 h / -20 - 20 °C / Inert atmosphere

With water; sodium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017