methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate

Base Information

• Chemical Name: methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate
• CAS No.: 136142-46-6
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 296.28
• Mol file: 136142-46-6.mol

Synonyms:methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate

Chemical Property of methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate

There total 4 articles about methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride (17193-40-7,67877-95-6,105359-55-5,108450-75-5) + bromoacetic acid methyl ester (96-32-2) → methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate (136142-46-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; 1.) room temp., 0.5 h, 2.) room temp., 2 h;

DOI:10.1021/jo00076a062

Reference yield: 36.0%

→ methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate (136142-46-6)

Guidance literature:

Reference yield:

(+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride (17193-40-7,67877-95-6,105359-55-5,108450-75-5) + methyl chloroacetate (96-34-4) → methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate (136142-46-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 50 ℃; for 72h;

DOI:10.1002/chem.200700543

upstream raw materials:

(+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride

bromoacetic acid methyl ester

4-nitrophenylalanine

methyl chloroacetate

Downstream raw materials:

3-(4-Nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane

3-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10,13,16-hexaazacyclooctadecane

2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid

2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane