p-NO2-Bn-DOTA(B-199)

Base Information

Chemical Name:p-NO2-Bn-DOTA(B-199)
CAS No.:116052-88-1
Molecular Formula:C23H33N5O10
Molecular Weight:539.53600
Hs Code.:
Mol file:116052-88-1.mol

Synonyms:

Suppliers and Price of p-NO2-Bn-DOTA(B-199)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
p-NO2-Bn-DOTA
1mg
$ 45.00

Total 4 raw suppliers

Chemical Property of p-NO2-Bn-DOTA(B-199)

Chemical Property:

Boiling Point:827.4±65.0 °C(Predicted)
PKA:2.46±0.10(Predicted)
PSA：207.98000
Density:1.362±0.06 g/cm3(Predicted)
LogP:-0.65930

Purity/Quality:

99% ^*data from raw suppliers

p-NO2-Bn-DOTA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses p-NO2-Bn-DOTA, is a Bifunctional chelator that can be used in the development of new molecule imaging agents for MRI and is highly suitable for chelation by IB-DOTA.

Technology Process of p-NO2-Bn-DOTA(B-199)

There total 11 articles about p-NO2-Bn-DOTA(B-199) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 135825-00-2
2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane

: 116052-88-1,123317-51-1
2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid

Guidance literature:: at 70 ℃; for 3h; at pH=10;
DOI:10.1021/ja00226a063

Reference yield: 46.0%

: 79-08-3
bromoacetic acid

: 135825-00-2
2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane

: 116052-88-1,123317-51-1
2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 70 ℃; for 4.5h;
DOI:10.1021/jo00076a062

Reference yield:

: 116052-91-6
2-(2-{2-[(S)-2-Amino-3-(4-nitro-phenyl)-propylamino]-ethylamino}-ethylamino)-ethanol

: 116052-88-1,123317-51-1
2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / Et₃N / acetonitrile / 8 h / Ambient temperature

2: 79 percent / Cs₂CO₃ / dimethylformamide / 5 h / 60 °C

3: 91 percent / 96percent H₂SO₄, C₆H₅OH / 48 h / 100 °C

4: 58 percent / 3 h / 70 °C / at pH=10

With sulfuric acid; caesium carbonate; triethylamine; phenol; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00226a063