2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one

Base Information

Chemical Name:2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one
CAS No.:1408445-62-4
Molecular Formula:C₂₉H₂₀O₃
Molecular Weight:416.476
Hs Code.:

Synonyms:2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one

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Chemical Property of 2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one

Chemical Property:

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Technology Process of 2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one

There total 11 articles about 2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1408444-65-4
2-iodo-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one

: 5720-07-0
4-methoxyphenylboronic acid

: 1408445-62-4
2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one

Guidance literature:: With palladium diacetate; sodium carbonate; In water; N,N-dimethyl-formamide; at 40 ℃; for 20h; Inert atmosphere;
DOI:10.1039/c2cc36127b

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 1408445-62-4
2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 23 - 25 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 23 - 25 °C / Inert atmosphere

3: iodine / 1,2-dichloro-ethane / 0 °C

4: palladium diacetate; sodium carbonate / water; N,N-dimethyl-formamide / 20 h / 40 °C / Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; palladium diacetate; sodium carbonate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling / 4: |Suzuki Coupling;
DOI:10.1039/c2cc36127b

Reference yield:

: 1408443-65-1
isopropyl 2-(3-hydroxy-3,3-diphenylprop-1-yn-1-yl)benzoate

: 1408445-62-4
2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one

Guidance literature:: Multi-step reaction with 2 steps

1: iodine / 1,2-dichloro-ethane / 80 °C

2: palladium diacetate; sodium carbonate / water; N,N-dimethyl-formamide / 20 h / 40 °C / Inert atmosphere

With iodine; palladium diacetate; sodium carbonate; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1039/c2cc36127b