(R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol

Base Information

Chemical Name:(R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol
CAS No.:1224568-02-8
Molecular Formula:C₂₂H₂₂F₃NO
Molecular Weight:373.418
Hs Code.:

Synonyms:(R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol

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Chemical Property of (R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol

Chemical Property:

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Technology Process of (R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol

There total 3 articles about (R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82572-04-1
(R)-<1-(1-Naphthyl)ethyl>ammonium chloride

: 1224568-02-8
(R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 0.08 h / microwave irradiation

2.1: sodium hydroxide; sodium tetrahydroborate / water; methanol / 0.5 h / -10 - 0 °C

2.3: pH 12 - 13

With sodium tetrahydroborate; sodium hydroxide; hydrogenchloride; In methanol; ethanol; water;

Reference yield:

: 1224567-99-0
3-{[(1R)-1-(naphthalen-1-yl)ethyl]amino}-1-[3-(trifluoromethyl)phenyl]propan-1-one hydrochloride

: 1224568-02-8
(R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol

Guidance literature:: 3-{[(1R)-1-(naphthalen-1-yl)ethyl]amino}-1-[3-(trifluoromethyl)phenyl]propan-1-one hydrochloride; With sodium hydroxide; In methanol; water; at 5 ℃; for 0.5h;

With sodium tetrahydroborate; sodium carbonate; In methanol; water; at 25 ℃;

Reference yield:

: 349-76-8
3'-(trifluoromethyl)acetophenone

: 1224568-02-8
(R)-3-(1-(naphthalen-1-yl)ethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 0.08 h / microwave irradiation

2.1: sodium hydroxide; sodium tetrahydroborate / water; methanol / 0.5 h / -10 - 0 °C

2.3: pH 12 - 13

With sodium tetrahydroborate; sodium hydroxide; hydrogenchloride; In methanol; ethanol; water;