82572-04-1 Usage
Uses
Used in Pharmaceutical Industry:
?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE is used as a building block for the synthesis of various pharmaceutical products due to its stable hydrochloride salt form and versatile chemical properties.
Used in Organic Chemistry:
?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE is used as a reagent for the preparation of a wide range of other compounds, leveraging its aromatic structure and amine functional group.
Used in Drug Synthesis:
?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE is used as a precursor in the synthesis of various drugs, including antihistamines and antidepressants, due to its aromatic structure and amine functional group, which contribute to the development of these therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 82572-04-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,5,7 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 82572-04:
(7*8)+(6*2)+(5*5)+(4*7)+(3*2)+(2*0)+(1*4)=131
131 % 10 = 1
So 82572-04-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H13N.ClH/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11;/h2-9H,13H2,1H3;1H/t9-;/m1./s1
82572-04-1Relevant articles and documents
Efficient synthesis and practical resolution of 1-(naphthalen-1-yl) ethanamine, a key intermediate for cinacalcet
Mathad, Vijayavitthal T.,Shinde, Gorakshanath B.,Ippar, Sharad S.,Niphade, Navnath C.,Panchangam, Raghavendra K.,Vankawala, Pravinchandra J.
, p. 341 - 346 (2011/04/15)
An efficient synthesis of 1-(naphthalen-1-yl)ethanamine (RS-2) and its practical resolution to optically pure (1R)-(naphthalen-1-yl)ethanamine (R-(+)-2), a key intermediate in the synthesis of cinacalcet hydrochloride (1), is described. The resolution of RS-2 using R-(-)-mandelic acid as a resolving agent in ethanol was established on an industrial scale to give pure R-(+)-2 with >99.8% ee after liberation of the amine from its mandelate salt. An efficient process for the racemization of undesired isomer S-(-)-2 is also provided to maximize the yield of desired enantiomer.
