cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

Base Information

Chemical Name:cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol
CAS No.:1432051-21-2
Molecular Formula:C₁₇H₁₆F₃NO₂
Molecular Weight:323.315
Hs Code.:

Synonyms:cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

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Chemical Property of cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

Chemical Property:

Purity/Quality:

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Technology Process of cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

There total 17 articles about cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

: 1432051-21-2
cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

Guidance literature:: With Chiralpak AD-H column; Resolution of racemate;

Reference yield:

: 1432050-70-8
3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanone

: 1432051-21-2
cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

: 1432051-28-9
trans-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

Guidance literature:: With sodium tetrahydroborate; In methanol; dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/acs.jmedchem.6b00287

Reference yield:

: 1432050-70-8
3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanone

: 1432051-21-2
cis-3-[(S)-hydroxy(pyridin-2-yl)methyl]-3-[3-(trifluoromethyl)phenyl]-cyclobutanol

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate / dichloromethane / 20 °C

2: Chiralpak AD-H column / Resolution of racemate

With methanol; sodium tetrahydroborate; In dichloromethane;