pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

Base Information

Chemical Name:pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol
CAS No.:1432050-71-9
Molecular Formula:C₁₉H₁₈F₃NO₃
Molecular Weight:365.352
Hs Code.:

Synonyms:pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

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Technology Process of pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

There total 5 articles about pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1432050-76-4
pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}-methanone

: 1432050-71-9
pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

Guidance literature:: With methanol; sodium tetrahydroborate; In dichloromethane; at 20 ℃;

Reference yield:

: 1379098-58-4
3-oxo-1-[3-(trifluoromethyl)phenyl]cyclobutanecarbonitrile

: 1432050-71-9
pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -75 °C

2.2: 3 h / -75 - 0 °C

3.1: methanol; sodium tetrahydroborate / dichloromethane / 20 °C

With methanol; sodium tetrahydroborate; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; hexane; dichloromethane;

Reference yield:

: 1432050-72-0
3-hydroxy-1-[3-(trifluoromethyl)phenyl]cyclobutanecarbonitrile

: 1432050-71-9
pyridin-2-yl{2-[3-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane / dichloromethane / 20 °C

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -75 °C

3.2: 3 h / -75 - 0 °C

4.1: methanol; sodium tetrahydroborate / dichloromethane / 20 °C

With methanol; sodium tetrahydroborate; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; Dess-Martin periodane; In diethyl ether; hexane; dichloromethane;