5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole

Base Information

Chemical Name:5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole
CAS No.:1366767-77-2
Molecular Formula:C₁₇H₁₉BrN₄O
Molecular Weight:375.268
Hs Code.:

Synonyms:5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole

Suppliers and Price of 5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole

There total 6 articles about 5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1366767-76-1
5-(4-bromophenyl)-1-[(3R)-3-pyrrolidinylmethyl]-1H-1,2,3-triazole

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1366767-77-2
5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole

Guidance literature:: 5-(4-bromophenyl)-1-[(3R)-3-pyrrolidinylmethyl]-1H-1,2,3-triazole; cyclopropanecarboxylic acid chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 138108-72-2
tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate

: 1366767-77-2
5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; sodium azide / dimethyl sulfoxide / 96 h

3: pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride / 1,2-dichloro-ethane / 8 h / 80 °C

4: hydrogenchloride / 1,4-dioxane / 2 h / 25 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 25 °C

With hydrogenchloride; sodium azide; N-ethyl-N,N-diisopropylamine; pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 177947-76-1
(3R)-1-(tert-butoxycarbonyl)-3-[(methane-sulfonyloxy)methyl]pyrrolidine

: 1366767-77-2
5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; sodium azide / dimethyl sulfoxide / 96 h

2: pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride / 1,2-dichloro-ethane / 8 h / 80 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 25 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 25 °C

With hydrogenchloride; sodium azide; N-ethyl-N,N-diisopropylamine; pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;