138108-72-2

Basic information

• Product Name: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3(R)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-N-BOC-PYRROLIDINE-3-METHANOL;(R)-1-tert-Butoxycarbonylpyrrolidine-3-methanol;(R)-1-Boc-3-hydroxymethylpyrrolidine;(3R)-3-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester;tert-butyl (3R)-3-(hydroxyMethyl)pyrrolidine-1-carboxylate;N-Boc-D-^b-prolinol, 97+%
• CAS NO: 138108-72-2
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.26
• EINECS: 1592732-453-0
• Product Categories: pharmacetical;Heterocycle-other series
• Mol File: 138108-72-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 289.5 °C at 760 mmHg
• Flash Point: 128.9 °C
• Appearance: /
• Density: 1.089
• Vapor Pressure: 0.000241mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 14.93±0.10(Predicted)
• Water Solubility: Slightly soluble in water
• CAS DataBase Reference: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(138108-72-2)
• EPA Substance Registry System: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(138108-72-2)

Safety Data

• Hazardous Substances Data: 138108-72-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a key intermediate for the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with different functional groups and properties.
Used in Pharmaceutical Industry:
(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a crucial building block in the development of new pharmaceuticals. Its chiral nature enables the synthesis of enantiomerically pure drugs, which can have significant advantages in terms of efficacy and safety.
Used in Agrochemicals:
(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can lead to improved performance and selectivity, reducing the environmental impact of these products.
Used in Dye Industry:
(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a starting material for the synthesis of various dyes and pigments. Its unique structure can contribute to the development of dyes with novel color properties and improved stability.

InChI:InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 99735-47-4 (3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine 
• 114214-69-6 tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 5082-74-6 (R)-(+)-3-(hydroxymethyl)pyrrolidine 
• 73286-71-2 N-(tert-butoxycarbonyl)-2,3-dihydropyrrole 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 191347-94-1 (R)-3-formylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 99724-15-9 methyl 5-oxo-1-((S)-1-phenylethyl)pyrrolidine-3-(R)-carboxylate 
• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 72925-16-7 (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid 
• 1123786-71-9 tert-butyl 2-(oxetan-3-yl)ethylcarbamate 
• 1165450-72-5 C₁₅H₂₇NO₅ 

Downstream Products

• 1018966-18-1 3-[(4-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}phenyl)thio]-N-(3-methyl-1,2,4-thiadiazol-5-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]pyridine-2-carboxamide 
• 1187932-69-9 (R)-tert-butyl 3-(iodomethyl)pyrrolidine-1-carboxylate 
• 1222140-13-7 tert-butyl 3(R)-(3-(benzyloxy)propyl)pyrrolidine-1-carboxylate 
• 1222140-23-9 C₁₂H₂₁NO₄ 
• 859213-51-7 (S)-1-(t-butoxycarbonyl)-3-(dimethylaminomethyl)pyrrolidine 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC AMIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION

Provided are a compound represented by formula (I) or a stereoisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt, eutectic mixture, or prodrug thereof, and a preparation method thereof, and an application for preparing a pharmaceutical product for treating a disease related to obstructed airways, wherein each substituent in the compound represented by formula (I) is as described in the specification.

Transition-metal-free synthesis of 3-(1-pyrrolidinyl)quinolines and 3-(1-pyrrolidinyl)quinoline 1-oxides via a one-pot reaction of 3-(1-pyrrolidinyl)crotonates with nitrobenzenes

A carbanion of tert-butyl 3-(1-pyrrolidinyl)crotonate adds to nitrobenzenes to form σH-adducts, which in the presence of pivaloyl chloride and triethylamine are converted into 3-(1-pyrrolidinyl)quinolines or 3-(1-pyrrolidinyl)quinoline 1-oxides depending on the nitrobenzene structure. This is the first methodology in which a quinoline ring is constructed from a substrate bearing a pyrrolidinyl ring. Starting from optically pure enamines, the method allows synthesis of the corresponding chiral products without racemisation.

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.

AZOLYL UREA COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are azolyl urea compounds for treatment of CSF-1R kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.

4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure-activity relationships

Single enantiomer [(aryloxy)(pyridinyl)methyl]piperidine and pyrrolidine derivatives 5-9 are inhibitors of monoamine reuptake. Structure-activity relationships established that monoamine reuptake inhibition are functions of amine, pyridine isomer, aryloxy ring substitution and stereochemistry. Consequently, selective NRIs, selective SRIs, dual SNRIs and triple SNDRIs were all identified. Dual SNRIs 5l-a and 9c were evaluated in additional pharmacology and pharmacokinetic studies as representative examples from this series.

Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the α6* subtype

Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands indicates that the pyrimidine substitution has the potential to enhance affinity and/or functional activity at α6 subunit-containing neuronal nicotinic rece

3,4-Methano-β-proline: A conformationally constrained β-amino acid

An enantiomerically pure, conformationally constrained β-proline derivative, 3,4-methano-β-proline, was synthesized starting with a readily available bicyclic lactone by using a straightforward synthetic route.

ANTITHROMBOTIC ETHERS

This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor (I).