138108-72-2

Basic information

• Product Name: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3(R)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-N-BOC-PYRROLIDINE-3-METHANOL;(R)-1-tert-Butoxycarbonylpyrrolidine-3-methanol;(R)-1-Boc-3-hydroxymethylpyrrolidine;(3R)-3-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester;tert-butyl (3R)-3-(hydroxyMethyl)pyrrolidine-1-carboxylate;N-Boc-D-^b-prolinol, 97+%
• CAS NO: 138108-72-2
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.26
• EINECS: 1592732-453-0
• Product Categories: pharmacetical;Heterocycle-other series
• Mol File: 138108-72-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 289.5 °C at 760 mmHg
• Flash Point: 128.9 °C
• Appearance: /
• Density: 1.089
• Vapor Pressure: 0.000241mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 14.93±0.10(Predicted)
• Water Solubility: Slightly soluble in water
• CAS DataBase Reference: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(138108-72-2)
• EPA Substance Registry System: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(138108-72-2)

Safety Data

• Hazardous Substances Data: 138108-72-2(Hazardous Substances Data)

Usage

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

InChI:InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 99735-47-4 (3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine 
• 1165450-72-5 C₁₅H₂₇NO₅ 
• 1123786-71-9 tert-butyl 2-(oxetan-3-yl)ethylcarbamate 
• 72925-16-7 (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid 
• 5082-74-6 (R)-(+)-3-(hydroxymethyl)pyrrolidine 
• 99724-15-9 methyl 5-oxo-1-((S)-1-phenylethyl)pyrrolidine-3-(R)-carboxylate 
• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 114214-69-6 tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 73286-71-2 N-(tert-butoxycarbonyl)-2,3-dihydropyrrole 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 191347-94-1 (R)-3-formylpyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1027542-53-5 (R)-tert-butyl 3-(benzyloxymethyl)pyrrolidine-1-carboxylate 
• 1035922-75-8 (R)-3-[2-(4-methoxybenzyl)-7-methyl-1-oxo-1,2-dihydro-isoquinolin-6-yloxymethyl]pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1187932-69-9 (R)-tert-butyl 3-(iodomethyl)pyrrolidine-1-carboxylate 
• 1222140-13-7 tert-butyl 3(R)-(3-(benzyloxy)propyl)pyrrolidine-1-carboxylate 
• 1222140-23-9 C₁₂H₂₁NO₄ 
• 274692-07-8 (R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate 
• 890849-28-2 (R)-tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate 
• 1187931-76-5 tert-butyl (S)-3-(cyanomethyl)pyrrolidine-1-carboxylate 
• 204688-60-8 (R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester 
• 1391730-27-0 tert-butyl (S)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate 
• 1443983-92-3 (S)-2-((R)-3-(fluoromethyl)pyrrolidin-1-yl)propan-1-ol 
• 1443983-95-6 (R)-3-(fluoromethyl)-1-((S)-1-(trityloxy)propan-2-yl)pyrrolidine 
• 1185303-79-0 (R)-3-(methoxymethyl)pyrrolidine hydrochloride 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC AMIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION

Provided are a compound represented by formula (I) or a stereoisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt, eutectic mixture, or prodrug thereof, and a preparation method thereof, and an application for preparing a pharmaceutical product for treating a disease related to obstructed airways, wherein each substituent in the compound represented by formula (I) is as described in the specification.

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.