Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester

Base Information

• Chemical Name: Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester
• CAS No.: 186641-91-8
• Molecular Formula: C₂₆H₄₀O₄SSi
• Molecular Weight: 476.753
• Mol file: 186641-91-8.mol

Synonyms:Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester

Chemical Property of Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester

There total 2 articles about Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2S,6R)-7-tert-butyldiphenylsilyloxy-2,6-dimethyl-1-heptanol (101382-88-1) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester (186641-91-8)

Guidance literature:

With pyridine; for 0.333333h; Ambient temperature;

DOI:10.1016/0040-4020(96)00916-7

Reference yield:

(E)-(2S,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,6-dimethyl-hept-3-en-1-ol → Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester (186641-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / H₂, sodium nitrite / 10percent Pd/C / methanol / 12 h

2: 98 percent / pyridine / 0.33 h / Ambient temperature

With pyridine; hydrogen; sodium nitrite; palladium on activated charcoal; In methanol;

DOI:10.1016/0040-4020(96)00916-7

Reference yield: 94.0%

Methanesulfonic acid (2S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester (186641-91-8) → ((2R,6S)-7-Bromo-2,6-dimethyl-heptyloxy)-tert-butyl-diphenyl-silane (186641-94-1)

Guidance literature:

With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

DOI:10.1016/0040-4020(96)00916-7

upstream raw materials:

(2S,6R)-7-tert-butyldiphenylsilyloxy-2,6-dimethyl-1-heptanol

methanesulfonyl chloride

Downstream raw materials:

((2R,6S)-7-Bromo-2,6-dimethyl-heptyloxy)-tert-butyl-diphenyl-silane

(3S,7R)-1-(8-bromo-3,7-dimethyloctyl)-2,6,6-trimethyl-1-cyclohexene

(3S,7R)-1-(3,7-dimethyl-8-formyl-octyl)-2,6,6-trimethyl-1-cyclohexene

(3S,7R)-1-(8-cyano-3,7-dimethyloctyl)-2,6,6-trimethyl-1-cyclohexene