(R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether

Base Information

• Chemical Name: (R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether
• CAS No.: 943816-06-6
• Molecular Formula: C₂₁H₃₀N₂OSi
• Molecular Weight: 354.567
• Mol file: 943816-06-6.mol

Synonyms:(R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether

Chemical Property of (R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether

There total 3 articles about (R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-1,4-bis(benzyloxycarbonyl)piperazin-2-ylmethyl tert-butyldiphenylsilylether → (R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether (943816-06-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 2h;

Reference yield:

(R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid (256446-66-9) → (R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether (943816-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 8 h / 20 °C

3: palladium on activated charcoal; hydrogen / ethanol / 2 h / 20 °C

With dmap; borane-THF; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

(R)-1,4-bis(benzyloxycarbonyl)piperazin-2-ylmethanol → (R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether (943816-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 8 h / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol / 2 h / 20 °C

With dmap; palladium on activated charcoal; hydrogen; triethylamine; In ethanol; dichloromethane;

upstream raw materials:

(R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid