(R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid

Base Information

• Chemical Name: (R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid
• CAS No.: 256446-66-9
• Molecular Formula: C₂₁H₂₂N₂O₆
• Molecular Weight: 398.415
• Mol file: 256446-66-9.mol

Synonyms:(R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid

Chemical Property of (R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid

There total 3 articles about (R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

benzyl chloroformate (501-53-1,94274-21-2) + (R)-piperazine-2-carboxylic acid (31321-68-3) → (R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid (256446-66-9)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 12h; pH=11;

Reference yield: 88.0%

C5H10N2O2*2C9H14O4S + di-tert-butyl dicarbonate (24424-99-5) + benzyl chloroformate (501-53-1,94274-21-2) → (R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid (256446-66-9) + (2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid (138775-02-7)

Guidance literature:

C₅H₁₀N₂O₂*2C₉H₁₄O₄S; benzyl chloroformate; With sodium hydroxide; In 1,4-dioxane; at 0 - 5 ℃; for 1.5 - 1.75h; pH=10.5 - 11.0;

With hydrogenchloride; water; pH=4.0;

di-tert-butyl dicarbonate; With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield: 86.0%

benzyl chloroformate (501-53-1,94274-21-2) + [2R,S]-piperazine-2-carboxylic acid dihydrochloride → (R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid (256446-66-9)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 12h; pH=11;

upstream raw materials:

benzyl chloroformate

di-tert-butyl dicarbonate

(R)-piperazine-2-carboxylic acid

Downstream raw materials:

C₂₂H₂₂N₄O₅

(R)-piperazine-2-ylmethyl tert-butyldiphenylsilylether

C₂₄H₂₈N₂O₆