N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide

Base Information

• Chemical Name: N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide
• CAS No.: 18780-56-8
• Molecular Formula: C₁₈H₁₉NO₅
• Molecular Weight: 329.353
• Mol file: 18780-56-8.mol

Synonyms:N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide

Chemical Property of N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide

There total 4 articles about N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-(methylenedioxy)benzoyl chloride (25054-53-9) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide (18780-56-8)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at 0 ℃; for 1.5h; Sealed tube;

DOI:10.1002/cjoc.201400471

Reference yield:

Piperonylic acid (94-53-1) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide (18780-56-8)

Guidance literature:

Piperonylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

2-(3,4-dimethoxyphenyl)-ethylamine; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1039/c4md00418c

Reference yield:

Piperonylic acid (94-53-1) → N-(3,4-dimethoxyphenethyl)-3,4-methylenedioxybenzamide (18780-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / chloroform / 2 h / Reflux

2: sodium hydroxide / dichloromethane; water / 1.5 h / 0 °C / Sealed tube

With thionyl chloride; sodium hydroxide; In dichloromethane; chloroform; water;

DOI:10.1002/cjoc.201400471

upstream raw materials:

Piperonylic acid

2-(3,4-dimethoxyphenyl)-ethylamine

3,4-(methylenedioxy)benzoyl chloride

Downstream raw materials:

N-(3,4-methylenedioxybenzyl)-3,4-dimethoxyphenylethylamine