tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Base Information

Chemical Name:tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate
CAS No.:1307813-53-1
Molecular Formula:C₂₉H₂₆F₃N₃O₅
Molecular Weight:553.538
Hs Code.:

Synonyms:tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

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Chemical Property of tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

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Technology Process of tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

There total 19 articles about tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1236144-52-7
tert-butyl azetidine-3-carboxylate acetic acid salt

: 1307813-52-0
3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazole-7-carbaldehyde

: 1307813-53-1
tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Guidance literature:: tert-butyl azetidine-3-carboxylate acetic acid salt; 3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazole-7-carbaldehyde; With methanol; titanium(IV)isopropoxide; acetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307813-53-1
tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

3.2: 20 °C

4.1: pyridine / dichloromethane / 20 °C

5.1: triethylamine / acetonitrile / 1.5 h / 0 - 20 °C

5.2: 1 h / 45 °C

6.1: thionyl chloride; pyridine / toluene / 0.5 h / 20 - 80 °C

7.1: trifluoroacetic acid / 0.75 h / 20 °C

8.1: sodium periodate / water; tetrahydrofuran / 0.5 h / 20 °C

9.1: methanol / titanium(IV)isopropoxide; acetic acid / dichloromethane / 1 h / 20 °C

9.2: 0.5 h / 20 °C

With pyridine; methanol; sodium periodate; N-chloro-succinimide; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triethylamine; trifluoroacetic acid; titanium(IV)isopropoxide; acetic acid; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 76240-27-2
7-hydroxy-2,3-dihydro-4H-chromen-4-one

: 1307813-53-1
tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / 2.58 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

4.1: (R)-10-camphorsulfonic acid / acetone / 20 °C

5.1: titanium tetrachloride / toluene / 0 - 20 °C

6.1: triethylamine / acetonitrile / 1.5 h / 0 - 20 °C

6.2: 1 h / 45 °C

7.1: thionyl chloride; pyridine / toluene / 0.5 h / 20 - 80 °C

8.1: trifluoroacetic acid / 0.75 h / 20 °C

9.1: sodium periodate / water; tetrahydrofuran / 0.5 h / 20 °C

10.1: methanol / titanium(IV)isopropoxide; acetic acid / dichloromethane / 1 h / 20 °C

10.2: 0.5 h / 20 °C

With pyridine; methanol; sodium periodate; osmium(VIII) oxide; thionyl chloride; titanium tetrachloride; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R)-10-camphorsulfonic acid; titanium(IV)isopropoxide; acetic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; acetone; toluene; acetonitrile;