rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate

Base Information

Chemical Name:rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate
CAS No.:118553-53-0
Molecular Formula:C₁₆H₂₄NO₇P
Molecular Weight:373.343
Hs Code.:

Synonyms:rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate

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Chemical Property of rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate

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Technology Process of rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate

There total 3 articles about rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 89525-07-5
(+/-)-2-<(benzyloxycarbonyl)amino>-2-(dimethoxyphosphinyl)acetic acid

: 75-65-0
tert-butyl alcohol

: 118553-53-0
rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In acetonitrile; 1.) 15 min, -10 deg C; 2.) 18 h, room temp.;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 89525-07-5
(+/-)-2-<(benzyloxycarbonyl)amino>-2-(dimethoxyphosphinyl)acetic acid

: 118553-53-0
rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate

Guidance literature:: With dmap; In tert-butyl alcohol; at 20 ℃; for 3h;
DOI:10.1016/S0040-4020(99)00753-X

Reference yield:

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 118553-53-0
rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 3.05 g / aq. NaOH / dioxane / 3.8 h / 20 °C

2: 2.26 g / DMAP / 2-methyl-propan-2-ol / 3 h / 20 °C

With dmap; sodium hydroxide; In 1,4-dioxane; tert-butyl alcohol; 1: Hydrolysis / 2: Etherification;
DOI:10.1016/S0040-4020(99)00753-X