(7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one

Base Information

Chemical Name:(7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one
CAS No.:1394132-07-0
Molecular Formula:C₁₆H₂₁NO₃
Molecular Weight:275.348
Hs Code.:

Synonyms:(7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one

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Chemical Property of (7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one

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Technology Process of (7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one

There total 1 articles about (7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1394132-12-7
methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate

: 1394132-07-0
(7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 18h; Inert atmosphere; Reflux;
DOI:10.1039/c2ob25689d

Reference yield: 94.0%

: 1394132-07-0
(7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one

: 1394132-08-1
(3R,9aS)-hexahydro-3-(4-methoxyphenyl)-1H-quinolizine-2,6-dione

Guidance literature:: With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c2ob25689d

Reference yield:

: 1394132-07-0
(7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one

: 1394132-09-2
(S)-4,6,7,8,9,9a-hexahydro-3-(4-methoxyphenyl)-6-oxo-1H-quinolizin-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere

2.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / 0 - 20 °C / Inert atmosphere

With sulfur trioxide pyridine complex; potassium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c2ob25689d