methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate

Base Information

Chemical Name:methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate
CAS No.:1394132-12-7
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

Synonyms:methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate

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Technology Process of methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate

There total 1 articles about methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 67-56-1
methanol

: 1394132-11-6
4-((2S,4S,5R)-1-(tert-butoxycarbonyl)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoic acid

: 1394132-12-7
methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate

Guidance literature:: With thionyl chloride; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1039/c2ob25689d

Reference yield: 73.0%

: 1394132-12-7
methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate

: 1394132-07-0
(7R,8S,9aS)-hexahydro-8-hydroxy-7-(4-methoxyphenyl)-1H-quinolizin-4(6H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 18h; Inert atmosphere; Reflux;
DOI:10.1039/c2ob25689d

Reference yield:

: 1394132-12-7
methyl 4-((2S,4S,5R)-4-hydroxy-5-(4-methoxyphenyl)piperidin-2-yl)butanoate

: 1394132-09-2
(S)-4,6,7,8,9,9a-hexahydro-3-(4-methoxyphenyl)-6-oxo-1H-quinolizin-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / Inert atmosphere; Reflux

2.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere

3.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

With sulfur trioxide pyridine complex; potassium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c2ob25689d