4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene

Base Information

Chemical Name:4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene
CAS No.:411235-99-9
Molecular Formula:C₂₃H₁₇F₃O₃
Molecular Weight:398.381
Hs Code.:

Synonyms:4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene

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Chemical Property of 4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene

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Technology Process of 4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene

There total 3 articles about 4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 411235-92-2
4-(4-acetoxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)chromen-2-one

: 411235-99-9
4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene

Guidance literature:: 4-(4-acetoxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)chromen-2-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With hydrogenchloride; at 60 - 65 ℃; for 3h;
DOI:10.1016/S0968-0896(01)00257-7

Reference yield:

: 351-35-9
3-(trifluoromethyl)phenylacetic acid

: 411235-99-9
4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 69 percent / Et₃N / 18 h / 135 °C

2.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

2.2: 79 percent / 6M HCl / 3 h / 60 - 65 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0968-0896(01)00257-7

Reference yield:

: 33257-86-2
(2-hydroxy-4-methoxyphenyl)-(4-hydroxyphenyl)-methanone

: 411235-99-9
4-(4-hydroxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)-2H-chromene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 69 percent / Et₃N / 18 h / 135 °C

2.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

2.2: 79 percent / 6M HCl / 3 h / 60 - 65 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0968-0896(01)00257-7