33257-86-2

Upstream product

• 41351-30-8 (4-hydroxyphenyl)(2,4-dimethoxyphenyl)methanone 
• 99-96-7 4-hydroxy-benzoic acid 
• 150-19-6 O-methylresorcine 
• 2237-36-7 4-methoxysalicylic acid 
• 108-95-2 phenol 

Downstream Products

• 97780-95-5 N-<2,4'-Dihydroxy-4-methoxydiphenylmethyl>phenethylimine 
• 411235-89-7 4-(4-acetoxyphenyl)-7-methoxy-3-(4-methoxyphenyl)chromen-2-one 
• 411235-91-1 4-(4-acetoxyphenyl)-3-(4-biphenyl)-7-methoxychromen-2-one 
• 411235-90-0 4-(4-acetoxyphenyl)-7-methoxy-3-(4-methylphenyl)chromen-2-one 
• 411235-95-5 4-(4-acetoxyphenyl)-7-methoxy-3-(3-methylphenyl)chromen-2-one 
• 411235-92-2 4-(4-acetoxyphenyl)-7-methoxy-3-(3-(trifluoromethyl)phenyl)chromen-2-one 
• 207278-56-6 4-(4-Acetoxyphenyl)-7-methoxy-3-(4-(trifluoromethyl)phenyl)coumarin 
• 411235-94-4 4-(4-acetoxyphenyl)-7-methoxy-3-(3-methoxyphenyl)chromen-2-one 
• 411235-93-3 4-(4-acetoxyphenyl)-3-(3-fluorophenyl)-7-methoxychromen-2-one 
• 207281-33-2 4-(4-acetoxyphenyl)-3-(4-fluorophenyl)-7-methoxy-coumarin 
• 33257-83-9 4-(4-hydroxyphenyl)-7-methoxy-3-phenyl-2H-chromen-2-one 
• 1450604-25-7 7-(2-morpholinoethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one 
• 1450604-24-6 7-(2-bromoethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one 
• 1450604-33-7 7-(2-(diethylamino)ethoxy)-4-(4-(2-(diethylamino)ethoxy)phenyl)-3-phenyl-2Hchromen-2-one 

Relevant academic research and scientific papers

Design, synthesis, and anti-tumor activities of novel triphenylethylene- coumarin hybrids, and their interactions with Ct-DNA

Novel triphenylethylene-coumarin hybrid derivatives containing different amounts of amino side chains were designed and synthesized in good yields under microwave radiation. The derivatives 5b-d which possessed two amino side chains (except morpholinyl) showed a broad-spectrum and good anti-proliferative activity against five tumor cells and low cytotoxicity in osteoblast. UV-vis, fluorescence, and circular dichroism (CD) spectroscopies and thermal denaturation exhibited that compounds 10c, 5c, and 13c bearing amino side chain (except morpholinyl) on 4-phenyl had significant interactions with Ct-DNA by the intercalative mode of binding. Structure-activity relationships (SARs) analysis suggested that the amino alkyl chain would play an important role both in the compounds against tumor cells proliferation and their interactions with DNA.

Lead identification of a potent benzopyranone selective estrogen receptor modulator

Starting from a phenol screening hit (6), three series of benzopyranone selective estrogen receptor modulators (SERMs) have been designed, synthesized, and analyzed for both estrogen receptor alpha binding affinity and in vitro activity in two cell assays. The lead compound identified, SP500263 (13), was more potent than raloxifene and tamoxifen in a cell-based assay measuring inhibition of interleukin-6 release.

Synthetic polystyrene resin and its use in solid phase peptide synthesis

A synthetic resin based on a polystyrene that can be used as a support for solid phase peptide synthesis and that has been cross-linked with from 0 to 5 mol % of divinyl benzene, characterized in that it has been substituted at benzene rings of its skelet