7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

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Chemical Name:7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one
CAS No.:187949-72-0
Molecular Formula:C₂₇H₂₄F₂N₆O₂
Molecular Weight:502.523
Hs Code.:

Synonyms:7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

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Chemical Property of 7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

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Technology Process of 7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

There total 4 articles about 7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 100-46-9
benzylamine

: 187949-13-9
(1R,2R)-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4triazol-1-yl)propyl]-7-fluoroquinazolin-4(3H)-one

: 187949-72-0
7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

Guidance literature:: In various solvent(s); at 120 ℃; for 96h;
DOI:10.1021/jm9707277

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 187949-72-0
7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: DCC, aq. HOBT, NEt₃ / dimethylformamide / 18 h / Ambient temperature

2: 5N aq. HCl / dioxane; various solvent(s) / 18 h / 110 °C

3: 66 percent / various solvent(s) / 96 h / 120 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm9707277

Reference yield:

: 127000-91-3
(2R,3R)-3-Amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 187949-72-0
7-Benzylamino-3-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: DCC, aq. HOBT, NEt₃ / dimethylformamide / 18 h / Ambient temperature

2: 5N aq. HCl / dioxane; various solvent(s) / 18 h / 110 °C

3: 66 percent / various solvent(s) / 96 h / 120 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm9707277