4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile

Base Information

Chemical Name:4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile
CAS No.:1580002-11-4
Molecular Formula:C₂₂H₁₈N₄O₂
Molecular Weight:370.411
Hs Code.:

Synonyms:4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile

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Chemical Property of 4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile

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Technology Process of 4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile

There total 4 articles about 4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1580002-04-5
2-chloro-4-(4-cyano-2,6-dimethylphenoxy)-6-methoxypyridin

: 873-74-5
4-Aminobenzonitrile

: 1580002-11-4
4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile

Guidance literature:: With palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.bmc.2014.01.054

Reference yield:

: 2402-78-0
2,6-dichloropyridine

: 1580002-11-4
4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid; dihydrogen peroxide / water / 3 h / Reflux

2.1: trichlorophosphate / 4 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 100 °C / Inert atmosphere

4.1: sodium methylate / 4 h / Reflux

5.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 100 °C / Schlenk technique; Inert atmosphere

With dihydrogen peroxide; sodium methylate; palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.01.054

Reference yield:

: 2587-00-0
2,6-dichloropyridine N-oxide

: 1580002-11-4
4-((2-((4-cyanophenyl)amino)-6-methoxypyridin-4-yl)oxy)-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 4 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 100 °C / Inert atmosphere

3.1: sodium methylate / 4 h / Reflux

4.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 100 °C / Schlenk technique; Inert atmosphere

With sodium methylate; palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; trichlorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.01.054