4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline

Base Information

• Chemical Name: 4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline
• CAS No.: 936112-84-4
• Molecular Formula: C₁₀H₁₁N₃O₂
• Molecular Weight: 205.216
• Mol file: 936112-84-4.mol

Synonyms:4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline

Chemical Property of 4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline

There total 1 articles about 4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

→ 4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline (936112-84-4)

Guidance literature:

Reference yield: 94.0%

4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline (936112-84-4) + ethyl bromoacetate (105-36-2) → ethyl N-[4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)phenyl]glycinate (1411034-16-6)

Guidance literature:

With triethylamine; potassium iodide; In toluene; for 24h; boiling;

Reference yield:

4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)aniline (936112-84-4) → dabigatran etexilate (211915-06-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / potassium iodide / toluene / 24 h / boiling

2.1: sodium hydroxide / 20 °C

2.2: pH 2

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 2 h / 20 - 50 °C

4.1: hydrogen; acetic acid / 5%-palladium/activated carbon / ethanol / 6 h / 50 °C / 3750.38 Torr / Inert atmosphere

4.2: 20 °C

5.1: potassium carbonate / ethanol; water; acetone / 0.33 h / 28 - 32 °C

With hydrogen; potassium carbonate; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; sodium hydroxide; 5%-palladium/activated carbon; potassium iodide; In ethanol; water; ethyl acetate; acetone; toluene;

Downstream raw materials:

ethyl N-[4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)phenyl]glycinate

dabigatran etexilate

N-[4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)phenyl]glycine

ethyl N-{[1-methyl-2-({[4-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate

Refernces