3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile

Base Information

• Chemical Name: 3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile
• CAS No.: 153168-49-1
• Molecular Formula: C₁₄H₁₂Cl₂N₂O₂
• Molecular Weight: 311.167
• Mol file: 153168-49-1.mol

Synonyms:3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile

Chemical Property of 3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile

There total 1 articles about 3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

chloroxynil (1891-95-8) + 3-(3-methylisoxazol-5-yl)propyl chloride (130800-76-9) → 3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile (153168-49-1)

Guidance literature:

With potassium carbonate; potassium iodide; In various solvent(s); at 60 ℃; for 60h;

DOI:10.1021/jm00041a022

Reference yield:

3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile (153168-49-1) → 3,5-Dichloro-N-hydroxy-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-benzamidine (153168-51-5)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; for 18h; Heating;

DOI:10.1021/jm00041a022

Reference yield:

3,5-dichloro-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile (153168-49-1) → 3-{3,5-Dichloro-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-phenyl}-5-methyl-[1,2,4]oxadiazole

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, hydroxylamine hydrochloride / ethanol / 18 h / Heating

2: 63.8 percent / pyridine / 1 h / Heating

With pyridine; hydroxylamine hydrochloride; potassium carbonate; In ethanol;

DOI:10.1021/jm00041a022

upstream raw materials:

chloroxynil

3-(3-methylisoxazol-5-yl)propyl chloride

Downstream raw materials:

3,5-Dichloro-N-hydroxy-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-benzamidine