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Usage

Uses

Used in Pharmaceutical Industry:
Isoxazole, 5-(3-chloropropyl)-3-methyl(9CI) is used as an intermediate in the preparation of Picornavirus replication inhibitors. These inhibitors are essential in the development of antiviral drugs targeting Picornaviruses, a family of RNA viruses that cause various illnesses, including the common cold, polio, and hepatitis A.
As an intermediate, Isoxazole, 5-(3-chloropropyl)-3-methyl(9CI) plays a crucial role in the synthesis of the final antiviral compounds. Its unique chemical structure allows for further functionalization and modification to enhance the potency and selectivity of the resulting Picornavirus replication inhibitors. This application is significant in the ongoing efforts to combat viral infections and develop new therapeutic strategies against emerging and existing viral diseases.

InChI:InChI=1/C7H10ClNO/c1-6-5-7(10-9-6)3-2-4-8/h5H,2-4H2,1H3

Upstream product

• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 540-51-2 2-bromoethanol 

Downstream Products

• 173900-34-0 3-Fluoro-5-iodo-4-[3-(3-methylisoxazol-5yl)propyloxy]phenylcyanide 
• 173900-31-7 3-Methyl-4-[3-(3-methylisoxazol-5yl)propyloxy]phenylcyanide 
• 173900-29-3 4-[3-(3-Methylisoxazol-5yl)propyloxy]phenylcyanide 
• 134472-29-0 3,5-dimethyl-4-(pent-4-yn-1-yloxy)benzonitrile 
• 152775-44-5 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole 
• 153168-13-9 acetic acid, <3-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-1,2,4-oxadiazol-5-yl>methyl ester 
• 153168-16-2 5-{3-[2,6-Dimethyl-4-(5-trichloromethyl-1,2,4-oxadiazol-3-yl)-phenoxy]propyl}-3-methylisoxazole 
• 153168-12-8 5-{3-[2,6-Dimethyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-3-methylisoxazole 
• 134472-33-6 3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzoic acid 2-acetylhydrazide 
• 156787-18-7 5-chloro-3-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-1,2,4-oxadiazole 
• 153168-51-5 3,5-Dichloro-N-hydroxy-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-benzamidine 

Relevant academic research and scientific papers

1,2,4-OXADIAZOLYL-PHENOXYALKYLISOXAZOLES AND THEIR USE AS ANTIVIRAL AGENTS

Compounds of the formula wherein: R1 is alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, alkoxyalkyl, hydroxyalkoxy, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy, or cyanomethyl; Y is alkylene of 3 to 9 carbon atoms, R2 and R3 independently are hydrogen, alkyl, alkoxy, halo, cyano, trifluoromethyl and nitro; R4 is alkoxy, hydroxy, halomethyl, dihalomethyl, trihalomethyl, dihaloethyl, cycloalkyl, heterocyclyl, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, alkanecarbonyloxyalkyl, cyano, halo, thioalkyl, alkylthioalkyl, alkylthio, thio, 2,2,2-trifluoro-ethyl, (4-methylphenyl)sulfonyloxymethyl, N=Q or CON=Q, where N=Q is amino, alkylamino or dialkylamino; R5 is hydrogen or halo or alkyl

1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Compounds of the formula STR1 wherein: R1 is alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, alkoxyalkyl or hydroxyalkoxy; Y is alkylene of 3 to 9 carbon atoms, R2 and R3 independently are hydrogen, alkyl, alkoxy, halo,

Conformationally restricted analogues of disoxaril: A comparison of the activity against human rhinovirus types 14 and 1A

A series of conformationally restricted analogs of disoxaril has been synthesized and evaluated against human rhinovirus types (HRV) 14 and 1A. The sensitivity of these serotypes to this series varied and was dependent upon the length of the molecule as w