21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione

Base Information

Chemical Name:21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione
CAS No.:1448329-09-6
Molecular Formula:C₂₈H₃₁ClO₂
Molecular Weight:435.006
Hs Code.:

Synonyms:21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione

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Technology Process of 21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione

There total 3 articles about 21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 110245-98-2
4-chloro-Δ^1,4-pregnadien-3,20-dione

: 100-52-7
benzaldehyde

: 1448329-09-6
21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 12h;
DOI:10.1016/j.steroids.2013.04.016

Reference yield:

: 1164-81-4
4-Chloro-pregn-4-ene-3,20-dione

: 1448329-09-6
21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 2 h / 0 °C / Reflux

2: potassium hydroxide / ethanol / 12 h / 20 °C

With tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; In 1,4-dioxane; ethanol;
DOI:10.1016/j.steroids.2013.04.016

Reference yield:

: 1164-27-8
4(α,β),5-epoxypregnyne-3,20-dione

: 1448329-09-6
21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / acetone / 1 h / Reflux

2: tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 2 h / 0 °C / Reflux

3: potassium hydroxide / ethanol / 12 h / 20 °C

With hydrogenchloride; tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; In 1,4-dioxane; ethanol; acetone;
DOI:10.1016/j.steroids.2013.04.016