2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol

Base Information

Chemical Name:2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol
CAS No.:848483-81-8
Molecular Formula:C₃₁H₃₂O₄S
Molecular Weight:500.659
Hs Code.:

Synonyms:2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol

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Chemical Property of 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol

Chemical Property:

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Technology Process of 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol

There total 7 articles about 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 591-51-5
phenyllithium

: 848483-79-4
(4-benzyloxy-phenyl)-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-acetaldehyde

: 848483-81-8
2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol

Guidance literature:: In tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.11.018

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 848483-81-8
2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: 85 percent / tetrahydrofuran

2.1: 95 percent / TPAP; NMO; 4 Angstroem molecular sieve / CH₂Cl₂

3.1: 85 percent / tetrahydrofuran

4.1: BH₃ / tetrahydrofuran

4.2: 90 percent / aq. H₂O₂; NaOH / tetrahydrofuran

5.1: 96 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂

6.1: 60 percent / tetrahydrofuran

With pyridine; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; borane; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 3.1: Tebbe olefination;
DOI:10.1016/j.bmcl.2004.11.018

Reference yield:

: 1-bromo-4-methoxy-2-methoxymethylsulfanylmethyl-benzene

: 848483-81-8
2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: 85 percent / tetrahydrofuran

2.1: 95 percent / TPAP; NMO; 4 Angstroem molecular sieve / CH₂Cl₂

3.1: 85 percent / tetrahydrofuran

4.1: BH₃ / tetrahydrofuran

4.2: 90 percent / aq. H₂O₂; NaOH / tetrahydrofuran

5.1: 96 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂

6.1: 60 percent / tetrahydrofuran

With pyridine; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; borane; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 3.1: Tebbe olefination;
DOI:10.1016/j.bmcl.2004.11.018