2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone

Base Information

• Chemical Name: 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone
• CAS No.: 848483-83-0
• Molecular Formula: C₃₁H₃₀O₄S
• Molecular Weight: 498.643

Synonyms:2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone

Chemical Property of 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone

Chemical Property:

Purity/Quality:

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Technology Process of 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone

There total 8 articles about 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol (848483-81-8) → 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone (848483-83-0)

Guidance literature:

With pyridine; Dess-Martin periodane; In dichloromethane;

DOI:10.1016/j.bmcl.2004.11.018

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone (848483-83-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: 85 percent / tetrahydrofuran

2.1: 95 percent / TPAP; NMO; 4 Angstroem molecular sieve / CH₂Cl₂

3.1: 85 percent / tetrahydrofuran

4.1: BH₃ / tetrahydrofuran

4.2: 90 percent / aq. H₂O₂; NaOH / tetrahydrofuran

5.1: 96 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂

6.1: 60 percent / tetrahydrofuran

7.1: 85 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂

With pyridine; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; borane; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 3.1: Tebbe olefination;

DOI:10.1016/j.bmcl.2004.11.018

Reference yield:

1-bromo-4-methoxy-2-methoxymethylsulfanylmethyl-benzene → 2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanone (848483-83-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: 85 percent / tetrahydrofuran

2.1: 95 percent / TPAP; NMO; 4 Angstroem molecular sieve / CH₂Cl₂

3.1: 85 percent / tetrahydrofuran

4.1: BH₃ / tetrahydrofuran

4.2: 90 percent / aq. H₂O₂; NaOH / tetrahydrofuran

5.1: 96 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂

6.1: 60 percent / tetrahydrofuran

7.1: 85 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂

With pyridine; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; borane; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 3.1: Tebbe olefination;

DOI:10.1016/j.bmcl.2004.11.018

upstream raw materials:

2-(4-benzyloxy-phenyl)-2-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-1-phenyl-ethanol

p-benzyloxybenzaldehyde

(4-benzyloxy-phenyl)-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-acetaldehyde

(4-benzyloxy-phenyl)-(4-methoxy-2-methoxymethylsulfanylmethyl-phenyl)-methanone

Downstream raw materials:

2-(4-benzyloxy-phenyl)-2-(2-mercaptomethyl-4-methoxy-phenyl)-1-phenyl-ethanone

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