(R)-methyl 3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoate

Base Information

• Chemical Name: (R)-methyl 3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoate
• CAS No.: 1100227-62-0
• Molecular Formula: C₂₉H₃₄F₃N₃O₆
• Molecular Weight: 577.601

Synonyms:(R)-methyl 3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoate

Chemical Property of (R)-methyl 3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoate

Chemical Property:

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Technology Process of (R)-methyl 3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoate

There total 1 articles about (R)-methyl 3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(R)-tert-butyl 4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate (1006706-48-4) + benzene 1,3-dicarboxylic acid monomethyl ester (1877-71-0) → (R)-methyl 3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoate (1100227-62-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2008.10.076

Reference yield: 78.0%

(R)-methyl 3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoate (1100227-62-0) → (R)-3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoic acid (1100227-43-7)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2008.10.076

upstream raw materials:

(R)-tert-butyl 4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

benzene 1,3-dicarboxylic acid monomethyl ester

Downstream raw materials:

(R)-3-(4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoic acid

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