Technology Process of ethyl 4-(4-ethynylphenoxy)butanoate
There total 5 articles about ethyl 4-(4-ethynylphenoxy)butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
DOI:10.1002/chem.201100390
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 14 h / 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere
2.2: 36 h / 50 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; sodium hydride; triethylamine;
In
tetrahydrofuran; mineral oil;
1.1: Sonogashira coupling;
DOI:10.1002/chem.201100390
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium iodide; potassium hydroxide / dimethyl sulfoxide; acetone / 48 h / 70 °C / Inert atmosphere
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / 24 h / 20 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; diisopropylamine; potassium iodide; potassium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide; acetone;
DOI:10.1002/adsc.201100600
