(R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol

Base Information

Chemical Name:(R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol
CAS No.:1421045-58-0
Molecular Formula:C₁₈H₂₆O₅
Molecular Weight:322.401
Hs Code.:

Synonyms:(R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol

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Chemical Property of (R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol

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Technology Process of (R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol

There total 1 articles about (R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 536-74-3
phenylacetylene

: 503321-04-8
(2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-[1,4]dioxane-2-carbaldehyde

: 1421045-58-0
(R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol

Guidance literature:: phenylacetylene; With zirconocene dichloride; trimethylaluminum; In n-heptane; dichloromethane; water; for 0.666667h; Inert atmosphere;

(2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-[1,4]dioxane-2-carbaldehyde; With methyllithium; In n-heptane; dichloromethane; water; toluene; at -25 ℃; for 4h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/asia.201200859

Reference yield: 72.0%

: 1421045-58-0
(R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol

: 545-06-2
trichloroacetonitrile

: 1421045-66-0
2,2,2-trichloro-N-((S,E)-4-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-2-phenylbut-3-en-2-yl)acetamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃; for 5.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/asia.201200859

Reference yield:

: 1421045-58-0
(R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol

: 1421045-70-6
(R)-methyl 2-phenyl-2-(2,2,2-trichloroacetamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 5.5 h / 0 - 20 °C / Inert atmosphere

2.1: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 20 °C / Inert atmosphere

2.2: 11 h / 50 - 55 °C / Inert atmosphere

With sodium periodate; ruthenium(III) trichloride hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrachloromethane; dichloromethane; water; acetonitrile; 1.1: |Overman Rearrangement;
DOI:10.1002/asia.201200859